Near-Field Optical Device for Bioimaging and Sensing

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It is known that in surface-enhanced Raman spectroscopy (SERS), the molecules on the metal surface typically experience undesired modifications due to at least the charge transfer effect, causing significant changes in their optical spectra and biological activity. As a result, the optical spectra often represent signatures of metal-molecule complexes rather than molecules themselves. In addition, the deposition of proteins on a metal surface can denature the molecules or cause other significant changes so that antibodies, for example, can lose their binding activity.

Purdue University researchers have developed a tunable super-lens (TSL) for nanoscale optical sensing and imaging of biomolecules and nanomanufacturing utilizing negative-index materials (NlMs) that operate in the visible or near infrared light. The resulting lens will perform subwavelength imaging, enhanced resolution imaging, or flat lens imaging. In particular, a frequency-controllable near field TSL can be arranged of a metal-dielectric film having an upper surface and a lower surface, a layer of a semiconductor medium bonded to the upper surface, and a layer of a semiconductor medium bonded to the lower surface. The semiconductor film (or a metal-dielectric film) can be made of Ag-Si02 composite, Si or SiC. Additional surface enhanced Raman scattering (SERS) substrate can be bonded to an outer surface of a first of the layers of the semiconductor medium. The TSL can be further equipped with a microfluidic channel.

Advantages:
-No undesirable molecule modification in SERS
-Molecules remain intact in SERS

Potential Applications:
-Surface-enhanced remote sensing of biomolecules using surface-enhanced Raman scattering (SERS)
-Detection of modification in spectra caused by the binding event using (SERS)
Sep 13, 2009
NATL-Patent
United States
8,599,489
Dec 3, 2013

Feb 26, 2008
PCT-Patent
WO
(None)
(None)

Feb 26, 2007
Provisional-Patent
United States
(None)
(None)
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