64752 | |
Advances in the treatment of HIV/AIDS with HIV-1 protease inhibitors in combination with reverse transcriptase inhibitors, known as highly active antiretroviral therapy (HAART), has resulted in improved life expectancy and significantly reduced HIV/AIDS-related mortality in the developed world. Unfortunately, HAART suffers from adverse drug side effects, poor oral bioavailability, and drug interactions. Also, drug-resistant HIV-1 variants have begun to emerge. Development of antiretroviral therapy with broad-spectrum activity and minimal side effects is needed for current and future HIV/AIDS treatment. Purdue University researchers have developed Darunavir, brand name Prezista, a drug used to treat HIV infection. Prezista was developed by the pharmaceutical company Tibotec and is an OARAC recommended treatment option for treatment-naive and -experienced adults and adolescents. It is also used in patients with drug-resistant HIV. The researchers have also developed a new generation of protease inhibitors that are exceedingly potent and maintain potency against multidrug resistant HIV-1 variants. Dr. Ghosh's laboratory has designed, synthesized, and evaluated several different series of compounds. These novel protease inhibitors show potent enzyme inhibitory, antiviral activity, and exceptional broad spectrum activity against highly cross-resistant mutant. Advantages: -Decreased adverse side effects -Effective against multidrug resistant HIV-1 variants -Improved bioavailability -Superior pharmacokinetic properties Potential Applications: -Medical/Healthcare -Pharmaceuticals -Drug Development -AIDS/HIV Treatment |
|
|
|
Jan 16, 2014
DIV-Patent
United States
9,359,317
Jun 7, 2016
Jun 6, 2016
DIV-Patent
United States
(None)
(None)
Jul 14, 2010
NATL-Patent
United States
(None)
(None)
Jan 16, 2009
PCT-Patent
WO
(None)
(None)
Jan 16, 2009
NATL-Patent
European Patent
(None)
(None)
Jul 25, 2008
Provisional-Patent
United States
(None)
(None)
Jan 17, 2008
Provisional-Patent
United States
(None)
(None)
Dec 5, 2006
Provisional-Patent
United States
(None)
(None)
|
|
Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org |