High Powered Laser Induced Acoustic Desorption Probe

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Mass spectrometry, in general, is a powerful technique for detection of minute or trace levels of compounds, and combinations thereof. With the development of electrospray ionization mass spectrometry (ESI) and matrix-assisted laser desorption ionization (MALDI), both soft evaporation/ionization methods, it became possible to nearly simultaneously evaporate and ionize large, thermally labile molecules. These advancements further enabled the use of mass spectrometry in biology and the life sciences. However, ESI and MALDI methods are biased toward polar and ionic compounds and are therefore not ideal for studying non-polar compounds in their natural state. Additionally, the ionization of analytes in ESI and MALDI is limited to protonation, deprotonation, or cation attachment, thus the study of nonpolar compounds remains difficult. Therefore, there exists a need for additional equipment and methods of preparing analytes that are not readily ionizable for analysis by mass spectrometry.
Researchers at Purdue University have developed a LIAD) mass spectrometry probe with a Fourier-transform ion cyclotron resonance mass spectrometer for the analysis of non-volatile, thermally labile analytes. This technology permits the generation of larger amplitude acoustic waves, improving the desorption efficiency of the molecular analysis. This improvement allows for higher measurement sensitivity than other methods, which provides an improved capability for detecting trace materials.

Advantages:
-Increased power density applied to the metal foil
-Improved desorption efficiency of molecules compared to conventional LIAD probes

Potential Applications:
-Desorption of non-volatile, thermally liable analytes for subsequent ionization and analysis
Apr 5, 2011
Utility Patent
United States
8,344,319
Jan 1, 2013

May 29, 2007
Utility Patent
United States
7,619,217
Nov 17, 2009

May 26, 2006
Provisional-Patent
United States
(None)
(None)
Purdue Office of Technology Commercialization
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Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org