Dithiocarbamate Ligands with Biosensing Applications

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The functionalization of metal substrates with organic ligands has become a standard practice in surface science and nanomaterials chemistry. Molecular monolayers are often formed spontaneously by a simple chemisorption process. The self-assembly of alkanethiols on gold is a method for preparing surfaces with tunable physical or chemical properties or with biological recognition elements. While such self-assembled monolayers (SAMs) have proven to be very useful, they are also limited by their chemical stability. Thiols can be readily oxidized to disulfides, sulfinates, or sulfonates and desorb or be displaced from the surface by other molecules. Alkanethiol-based SAMs have been shown to lack the long-term stability necessary for most biomedical applications.

Purdue University researchers have developed an innovative method for coating metal surfaces with dithiocarbamate (DTC) ligands. DTC ligands can absorb onto metal surfaces with the same degree of generality as thiols, but with greater resistance to surface desorption or displacement. DTC ligands can be formed under extremely mild conditions and are especially useful for robust functionalization of metal substrates and nanoparticles intended for biological labeling and biosensing applications.

Advantages:
-Can withstand a wide range of environments including a pH range of 1 to 12
-Resistant to displacement by competing surfactants
-Increased stability under physiological conditions

Potential Applications:
-Biological Labeling
-Biosensing
Apr 20, 2006
United States
7,803,568
Sep 28, 2010

Sep 10, 2007
United States
(None)
(None)

Apr 20, 2005
Provisional-Patent
United States
(None)
(None)
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