Improved BioCD Detects Molecular Structures in Samples

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In many chemical, biological, medical, and diagnostic applications, it is desirable to detect the presence of specific molecular structures in a sample. Many molecular structures, such as cells, viruses, bacteria, toxins, and DNA fragments, are recognized by particular receptors. One such technology for screening for a plurality of molecular structures is the so-called immunological compact disk, which simply includes an antibody microarray. Current methodologies have proven useful thus far, but are often characterized by large surface areas per element, long interaction lengths, or complicated resonance structures. Previously, a BioCD technology was developed to solve these problems, but it suffered from data that was corrupted by background noise.

Researchers at Purdue University have developed an improved BioCD technology that allows for very accurate and fast scans of biological binding sites. This technology makes possible a simple disk fabrication for spinning-disk immunoassays. It also establishes a common global quadrature for the entire disk, as opposed to each array element establishing its own quadrature condition. This will greatly facilitate disk fabrication with little or no effect of fabrication on the read fidelity. The system also has 100 percent light detection efficiency and automatic compensation of laser intensity drift. It can be implemented with differential encoding that directly subtracts out non-specific binding.

Advantages:
-Establishes global quadrature
-100 percent light detection efficiency
-Automatic compensation of laser intensity

Potential Applications:
-Biological structure detection
Feb 1, 2006
United States
7,663,092
Feb 16, 2010

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