High-Speed Multispectral Discrimination Technology, Flow Cytometry

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Current fluorescence intensity-based techniques are well-established in traditional screening methods that are used in diagnostic instruments. These methods rely on organic fluorochromes and emission band-detection systems. Although very powerful, they are restricted to approximately one dozen simultaneous fluorescent probes due to their design. Complex spectral compensation, complicated and numerous optics, and restricted spectral bandwidths make the current technology less efficient than desired.

Purdue University researchers have developed a new technology that allows high speed analysis of single particles for classification. Characteristics of this technology include advanced spectral analysis, high speed detection, and single particle discrimination capabilities. The basic principles of flow cytometry, image collection systems, image analysis, and signal processing are utilized. This technology's advanced detectors, signal separation processes, and analytical processes combine to provide new opportunities for cellular classification systems, such as clinical pathology, analytical cytology, or advanced pharmaceuticals in cellular systems.

Advantages:
-High-speed detection of multiple labeling molecules and single particle discrimination capabilities
-Reduces size and cost of systems
-Allows greater versatility in fluorescent combinations

Potential Applications:
-Medical/Health
-Diagnostics
Apr 8, 2005
Utility Patent
United States
7,280,204
Oct 9, 2007

Apr 8, 2005
PCT-Patent
WO
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Sep 23, 2004
Provisional-Patent
United States
(None)
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Sep 22, 2004
Provisional-Patent
United States
(None)
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Apr 8, 2004
Provisional-Patent
United States
(None)
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Purdue Office of Technology Commercialization
1801 Newman Road
West Lafayette, IN 47906

Phone: (765) 588-3475
Fax: (765) 463-3486
Email: otcip@prf.org