Novel Immunocompetent Breast Cancer Mouse Model

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Various monoclonal antibody-based treatments for breast cancer exist at different stages of development. Present technologies utilize the nude mouse model of breast cancer, which is not a true reflection of what may occur in normal animals in response to such treatments.

Purdue University researchers found the receptor tyrosine kinase EphA2 is over-expressed in breast cancer cells, and therefore, provides a unique target for breast cancer intervention. An immunocompetent mouse model of breast cancer has been developed for evaluating various therapeutic approaches including those involving activation or inhibition of EphA2.

Advantages:
-Improved mouse model of breast cancer

Potential Applications:
-Drug development
-Therapy evaluation
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