Proteomics with Isotope Ratio Quantification

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Protein analyzing is of major importance in the field of genetic research. When analyzing complex proteins the typical strategy is to cleave the proteins with an enzyme and then search the DNA database for fragments that match the mass of the signature peptide. Too often the complex mixtures contain thousands of proteins that may have a hundred thousand or more signature peptides. This causes the process to be extremely lengthy.

Researchers at Purdue University have developed a new method for this process. This method is as sensitive to changes in very dilute samples as it is with those that are present with great abundance. This approach also creates an internal standard that makes it easier to measure the changes at these low levels. By targeting the specific signature peptides it is possible to reduce the amount of time necessary for identification.

Advantages:
-Extremely sensitive detection
-Reduced detection time

Potential Applications:
-Database Management
-Genetics
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Purdue Office of Technology Commercialization
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West Lafayette, IN 47906

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