| 99046 | |
| Liposome-encapsulated drugs have used both passive and active targeting schemes to specifically deliver their payloads to target tissues in vivo. Unfortunately, existing methods for transporting the liposomal contents to the targeted cell cytoplasm are either inefficient or lack sufficient stability for practical therapeutic applications. Researchers at Purdue University have developed novel materials capable of inducing phase changes (fluid-gel, lamellar-hexagonal, hexagonal-isotropic) upon exposure to mildly oxidative or acidic conditions. The responsiveness of these materials is dependent on the degree of the applied stress; for example, no phase change occurs at pH7, whereas pH5 and pH 11 cause phase changes on the hours and minutes timescales, respectively. These materials are appropriate for controlled release in biomedical applications, including drug and gene delivery, polymer hydrogels, and tissue engineering, as well as formulations in the personal care products, food processing, and surfactant industries. Advantages: - Novel, liposome forming molecules - Biocompatible and externally controllable - Cost effective - Improves cytoplasmic delivery of liposome contents Potential Applications: -Medical/Healthcare -Pharmaceuticals -Drug development -Food industry |
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May 7, 2002
Utility Patent
United States
6,979,460
Dec 27, 2005
Jul 17, 2000
PCT-Patent
WO
(None)
(None)
Jul 17, 2000
NATL-Patent
European Patent
(None)
(None)
Jul 30, 1999
Provisional-Patent
United States
(None)
(None)
Jul 16, 1999
Provisional-Patent
United States
(None)
(None)
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Purdue Office of Technology Commercialization The Convergence Center 101 Foundry Drive, Suite 2500 West Lafayette, IN 47906 Phone: (765) 588-3475 Fax: (765) 463-3486 Email: otcip@prf.org |
