Creating Chiral Organoalanes and Organic Derivatives

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Catalytic enantioselective carbon-carbon bond formation is a highly desirable but difficult synthetic task when it involves simple alkenes without heteroatom function groups.

Researchers at Purdue University have developed a method that uses Zr-catalyzed asymmetric carboalumination of alkenes to produce chiral alkylalanes. These chiral alkylalanes can then be converted to various chiral organic compounds, such as isoalkyl alcohols and other organic compounds of interest, which can then be used in the production of vitamins, pharmaceuticals, and other medicinally and biologically important compounds. This process also yields isoalkyl alcohols with a high enantiomeric excess (e.e.), often exceeding 95% e.e.

Advantages:
-Can be used in production of various organic compounds of interest
-Yields isoalkyl alcohols with high enantiomeric excess

Potential Applications:
-Chemical Analysis
-Pharmaceuticals
-Medical/Healthcare
Oct 14, 1997
United States
6,002,037
Dec 14, 1999

Oct 15, 1996
Provisional-Patent
United States
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PCT-Patent
WO
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Purdue Office of Technology Commercialization
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